Siglecs as targets for therapy in immune-cell-mediated disease
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چکیده
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متن کاملSiglecs in the immune system.
Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins characterized by an N-terminal V-set Ig domain that mediates sialic acid binding, followed by varying numbers of C2-set Ig domains (Fig. 1). The initial discovery of this lectin family came about through independent studies on sialoadhesin (Siglec-1/CD169), a macrophage lectin-like adhesion molecule, and CD22 (Siglec-2),...
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15 صفحه اولProline Rich Motifs as Drug Targets in Immune Mediated Disorders
The current version of the human immunome network consists of nearly 1400 interactions involving approximately 600 proteins. Intermolecular interactions mediated by proline-rich motifs (PRMs) are observed in many facets of the immune response. The proline-rich regions are known to preferentially adopt a polyproline type II helical conformation, an extended structure that facilitates transient i...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2009
ISSN: 0165-6147
DOI: 10.1016/j.tips.2009.02.005